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FIGURE 4 4.2 Enhanced CDT and ferroptotic therapy In the past few decades, CDT has become an emerging invasive TME-responsive cancer treatment based on Fenton or a Fenton-like reaction, which uses transition metal (including Fe, Mn, and Cu) to convert endogenous abundant H 2 O 2 into highly toxic OH, contributing to irreversible cellular damage

This chapter will refer to primary or acute effects as those effects that begin within the first minutes after injury, secondary or subacute effects as those that arise over the next 24 hours after injury, and long-term or chronic effects as those that are associated with the insult but occur at a later time