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B12 Supplements (MAJOR EFFECT) Oral B12 Supplements: Typical dose: 1000 mcg (1 mg) Absorption: ~1-2% passively absorbed (10-20 mcg from 1000 mcg dose) Effect on serum B12: Can increase by 100-300 pg/mL within 24 hours Peak effect: 4-8 hours after oral supplement Intramuscular B12 Injections: Dose: Usually 1000 mcg Effect: Massive increase in serum B12 Can reach 1000-5000 pg/mL within hours Sustained elevation for weeks Recommendation: Stop oral supplements 3-7 days before testing (ideally 7 days) Wait 1-2 weeks after injection before testing 2

Cholecalciferol (D3) Injection Cholecalciferol Injection (Vitamin D3) (Grapeseed Oil) (5 mL Vial) Product Overview Cholecalciferol (Vitamin D) Injection 100,000 IU/mL is a sterile, oil-based compounded solution prepared in grapeseed oil for deep intramuscular use when patients require rapid or dependable vitamin D repletion because oral preparations are ineffective, poorly absorbed, or impractical

I had been fine using the out of date B12 (04/2022) until I suspect a couple of months ago when I began feeling a fair bit weaker, more noticeable to me when out cycling

If you take B12 supplements and your level is high, thats almost always the explanation