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doi: 10.1126/science.1234192 94 MurphyB
doi: 10.1177/25424823251347260 267 PandeyPVermaMLakhanpalSPandeySKumarMRBhatMet al
This arrangement allows for limited rotation and bending between adjacent vertebrae and enables the intervertebral disc (IVD) to withstand circumferential loads (Mohd Isa et al., 2022)
These effects were blocked by sulfasalazine, an inhibitor of the xCT transporter, which incorporates cystine (precursor of GSH) and extrudes extracellular glutamate, an agonist of the inhibitory mGlu2/3 receptor, which lowers the synaptic glutamatergic tone
