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Importantly, the authors of this work similarly did not interpret their findings related to cerebrovascular resistance as negative adaptations to RT, but instead consider the increase to be a protective response to reduce the effects of increased mean arterial pressure on the cerebral circulation - where hyperperfusion can damage the microvasculature (Thomas et al., 2021)

15,73,75 The olfactory region is considered the main region for the nose-to-brain delivery and provides a direct route that involves mechanisms of extracellular/paracellular diffusion and intracellular absorption into the olfactory neurons

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[DOI] [PubMed] [Google Scholar] 200.Contato A.G., Conte-Junior C.A