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Aberrant activation of the RhoA/ROCK signaling pathway is linked to various diseases, including vascular conditions and tumor metastasis

Octadecanoids in the Mammalian Skin Permeability Barrier The integrity of the mammalian skin permeability barrier depends on octadecanoids and specifically on LA and its LOX products

Differentially expressed between tissues, SLC22A4 is notably highly expressed both on the apical membrane of the small intestine where it functions in a pH-dependent fashion to take ergothioneine up from the diet (29) and on the apical membrane of proximal tubular cells in the kidney where it functions in renal reabsorption (30)