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Currently, the space is dominated by Eli Lilly and Novo Nordisk, which market tirzepatide and semaglutide, respectively, and which have effectively cornered the diabetes and obesity markets for GLP-1 drugs

The uMMA test may be more useful than the serum MMA test, because people with B12 deficiency and neurological damage excrete significantly more uMMA than those without damage

N-terminal acetylation and C-terminal amidation are standard peptide chemistry modifications that preserve the core pharmacophore while improving resistance to enzymatic degradation

Long-term effects of repeated cycles have not been mapped in published Western trials