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MOTS-c, by contrast, is not derived from hGH at all its research relevance comes from mitochondrial retrograde signaling, a communication pathway between mitochondria and the rest of the cell that governs how energy production adapts under metabolic stress

doi: 10.1001/jamaneurol.2025.0241, [DOI] [PMC free article] [PubMed] [Google Scholar] 43.Meyer TA-O, Schumann P, Weydt P, et al

Therefore, we reasoned that PrP might stimulate Cu uptake and, thereby, toxicity in ATP7B-deficient cells, while PrP suppression could counteract this process