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Keywords: Adrenal gland, Cortisol, Epinephrine, Hypothyroidism, Vitamin B12 Introduction The adrenal glands are key organs in the endocrine system that play crucial roles in the hormonal regulation of immune responses (Pignatti and Flck, 2021) as the cortex secretes steroid hormones that regulate body homeostasis in response to chronic stress, while the medulla synthesizes epinephrine and norepinephrine that modulate acute stress response (Connell and Davies, 2005)