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Description
There are three activities of the MTHFD1 encoded enzyme that include, N 5 , N 10 -methenyl-THF (5,10-methenyl-THF) cyclohydrolase, 5,10-methylene-THF dehydrogenase, and 10-formyl-THF synthetase
The median PFS and median OS for MET-amplified patients was 3.7 and 5.7 months, respectively compared to median PFS and median OS of 2.5 and 12.1 months, respectively, in patients without MET amplification (Jia et al., 2022)
Primary Handling Editor: Jerome Staal, in collaboration with the Nature Medicine team
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