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doi: 10.3390/biom11020185 21 HuthTEaton-FitchNStainesDMarshall-GradisnikS
Malignant brain tumors known as glioma or glioblastoma exploit this phenomenon by using glutamate as an energy source, especially when these tumors become more dependent on glutamate due to mutations in the gene IDH1
doi: 10.1684/ecn.2011.0294
Clinical translation of such strains is constrained by stringent regulations in some jurisdictions, including the European Union (von Wright, 2005), yet they remain invaluable research tools for elucidating mechanisms and hold promise for future use in tightly controlled medical settings
