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These alterations, in turn, can engage host BA receptors like Farnesoid X Receptor (FXR) and Takeda G protein-coupled Receptor 5 (TGR5/GPBAR1) on immune and cancer cells, thereby influencing anti-tumor immune responses and the efficacy of treatments such as immune checkpoint inhibitors (ICIs)

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Its normal to lose around 50 to 100 hairs per day during this phase

The exact reasons for this have not been fully established but been suggested to be the effect of Arg-112 making ApoE4 in a tighter locked conformation than ApoE3 or ApoE2, thus hindering the lipid insertion site (Chen et al., 2021