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Conversely, treatment of EGFR-dependent, tamoxifen-resistant breast cancer cells with the EGFR-selective TKI gefitinib led to activated IGF-1R signaling and subsequent resistance to EGFR inhibition [49]

As research has deepened, disease assessment tools and comorbidity relationships have been emphasized, with the rise of meta-analyses indicating a growing need for evidence integration

Neuroprotective effects Triphala treatment significantly improved cognitive function in C57BL/6 and 5xFAD, APP/PS1 transgenic mouse models of Alzheimers disease by modulating the amyloid precursor protein (APP) pathway, reducing amyloid plaque formation and neuroinflammation, and restoring the gut-brain axis

smegmatis was unexpected as NAD + -GDH enzymes are presumed to be largely involved in glutamate catabolism