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Immediately after antibody labeling of TNR, the antibodies are found mostly on the surface, as expected, and neurites are fully visible
PMID: 6538743
These changes form the basis of the prooxidant state and lead to altered redox signaling related to glutathione deficiency and impaired expression and function of redox-sensitive transcriptional factors (Nrf2, NF- B, FoxO, etc.)
Sleep disruption in FM may impair NRF2-driven antioxidant responses, leading to increased oxidative stress and neuroinflammation, which further exacerbate pain and fatigue (30)
