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d Data are expressed as mean standard deviation (SD)

Other destructive approaches include focused ultrasound [65] , CO 2 laser, radiofrequency ablation [66] , photodynamic therapy [67,68] , Er:YAG or Nd:YAG laser [69] , and electrodessication [70]

As a newly emerging and extensively studied pathway, iron dysregulation is activated early in AD pathogenesis and exhibits substantial cross-talk with classical pathological features such as A deposition and tau hyperphosphorylationrendering it a promising target for biomarker development