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Medical device manufacturers and sponsors should take timely steps to manage TGA annual charges for medical device entries and avoid unnecessary fees

As discussed in this review, increased recognition of the important role of metabolic reprogramming in the pathophysiology of GBM has highlighted new opportunities to exploit the tumors bioenergetics as potential treatment vulnerabilities

2015;10:e0121147

The major location, within the brain, for norepinephrine synthesis is the locus coeruleus of the brainstem
