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Weight loss : Retatrutide showed 28.7% at 68 weeks (Phase 3 TRIUMPH-4) versus CagriSema's 20.4% at 68 weeks (Phase 3 REDEFINE 1), though cross-trial comparisons are limited

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Whereas GLP-1 agonists act on the glucagon-like peptide-1 receptor within the incretin system, cagrilintide's targets sit in the amylin and calcitonin receptor family

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