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however, it has also been established that 2-oxo acid dehydrogenases, particularly pyruvate dehydrogenase complex (PDC) and 2-oxoglutarate dehydrogenase complex (OGDHC, also known as ketoglutarate dehydrogenase), are oxidant generators under permissive conditions and are themselves subject to redox modifications [4-9]

Supplementary Figure 4 confirms the statistical significance of this comparative proteomics through Power Analysis, and shows the YY vs

While not necessarily a clinically applicable strategy, this discovery raised the intriguing possibility that with a better understanding of the molecular pathways responsible for this injury, treatments could be developed to further reduce morbidity and mortality in AMI

[DOI] [PMC free article] [PubMed] 183.Krikorian R, Shidler MD, Summer SS, Sullivan PG, Duker AP, Isaacson RS, et al