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The easiness of formation of such covalent bond depends on overall redox potential of environment as well as pH (at low pH the equilibrium is shifted to the reduced, -SH form, under more basic conditions the -SH group is more willing to be oxidized and replaced by -SR, where R is anything except for hydrogen)

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The results obtained using different methods are still insufficiently harmonised, which is thought to result from the effect of the apo(a) molecule size variability on Lp(a) immunoassays

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