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Patients who already have exceptionally high pyridoxine levels or signs of pyridoxine toxicity (such as sensory neuropathy) should not continue to receive high-dose supplementation until those symptoms resolve
Proper site rotation minimizes recurrence
Thats why many people choose to take regular vitamin D supplements if they suffer from joint pain (such as Vitamin D3 5000 IU)
For vegans who do not supplement, slight differences in enterohepatic circulation may determine how long one can go before developing B12 deficiency symptoms (8)
