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In general, the probe should be absorbed exclusively via the paracellular pathway, be metabolically inert and freely filtered at the glomerulus without tubular reabsorption ( The most commonly used test evaluates the differential urinary excretion of the disaccharide lactulose and the sugar alcohol mannitol
doi: 10.2165/00023210-200923070-00003 193 ZarateC
8), also as observed in Fd proteins 30
A provoking agent such as EDTA is used in order to release the heavy metals into the blood stream which are then filtered via the kidneys and measured in the urine
