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1 Introduction Hepatocellular carcinoma (HCC) is the most frequent malignant tumor of the liver, with the highest occurrence among people with chronic liver disease ( Ferroptosis is an iron-dependent controlled cell death caused by polyunsaturated fatty acid-containing phospholipids (PL-PUFA) in cell membranes that differentiates from other types of cell death by iron-dependent accumulation of lipid peroxides and redox imbalance ( 2 The mechanism of ferroptosis The rise in ROS surpasses the regulating capacity of glutathione (GSH) and GPX 4, resulting in lipid peroxidation ( Figure 1 )

Polymer 2025 , 339 , 129186

At high altitude, as well as under other hypoxic conditions, increased levels of soluble 5-nucleotidase, ecto (encoded by the NT5E gene), a normally membrane-associated enzyme, result in increased conversion of extracellular AMP to adenosine

however, some persons have severe, diazoxide-unresponsive hypoglycemia