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Pathological Hallmarks of Alzheimer Disease A formal diagnosis of AD requires the presence of both senile plaques, which are composed of aggregated fibrils of A (mostly 42 and 40 amino acids in length) together with dystrophic neurites and neurofibrillary tangles, which are composed of aggregates of hyperphosphorylated Tau protein (98, 99)

They are classified into different types, including immunosensors, aptasensors, peptide-based sensors, and MIPs-based sensors based on bioinspired recognition elements (Fig