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843 Recent research has also explored haploidentical transplantation as a potential treatment option

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Under normal physiological conditions, about 3% of cytosolic glucose is processed via the polyol pathway, however, at higher concentrations of glucose, about 30% of the glucose enters the polyol pathway which makes it important in disposing of the glucose molecules and subsequent conversion to sorbitol [128]

In an 8-week study, 9 out of 10 subjects experienced a median reduction of one full ranking unit [0-4]