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Transdermal patches are less likely to cause unpleasant side effects such as nausea, diarrhea, constipation, and upset stomach
2,12-14 Many of these have a strong relationship with cognitive dysfunction, which is enhanced by oxidative stress
This route is particularly valuable for targeting the central nervous system, as it allows certain peptides and proteins to bypass the bloodbrain barrier (BBB), which typically restricts entry of large or hydrophilic molecules into the brain
Oliver, A
