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Mechanistically, EPA and DHA effectively reduced CUMS-induced expression of IL-1, IL-6, TNF-, microglial marker M Integrin alpha M (CD11b), and increased expression of astrocyte marker glial fibrillary acidic protein (GFAP) by regulating the NF-B/p38 signaling pathway (Yang et al., 2019)

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Also, the melanocytes (melanin-producing cells) will produce dark spots on the skin in a protective response to these environmental threats, such as sun damage