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An extensive overview of all FDA-approved drugs (19002019) with a known covalent mechanism of action that lists their therapeutic application along with the electrophilic warhead has been compiled by De Vita [20]

In addition, mitochondria are the main production sites of reactive oxygen free radicals [12]

however, in exceptional circumstances, a substance or method may be added to the Prohibited List at any time

The histological analysis was performed using a high power objective (x63) in the microscope ZEISS AXIOSKOP 2, by counting cells in three areas with a minimum of approximately 100 m 2 , using three distinct serial sections (50 m interval between sections) per animal, for five different animals