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The over dosage of copper is toxic to cells because it interferes with glycolytic enzymes, such as hexokinase and phosphofructokinase 1, as well as other enzymes, such as phosphoglyceric kinase, 6-phosphogluconate dehydrogenase, catalase and glutathione peroxidase [21, 22, 28]

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For example, from the approved NADs, ASO drugs often do not require carriers for efficient delivery and only require appropriate modifications, such as PS and 2 position modifications

Adipocyte iron levels impinge on a fat-gut crosstalk to regulate intestinal lipid absorption and mediate protection from obesity