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The stabilized HIF-1 activates the expression of VEGF, leading to rich vascularization, which seems like a vicious cycle, then resulting in worse patient outcome and malignancy signs [8, 9]

This could also explain why the GluK3 receptors might desensitize faster even at sub-saturating glutamate concentrations consistent with the function of GluK3 receptors at the mossy-fiber CA3 hippocampal cell synapse 11

J Clin Psychopharmacol 2000;20(3): 394-395

This helps to support and disperse the Aqualyx liquid solution in the treated area faster
