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Studies have shown that its analgesic properties are dose-dependent and involve multiple pathways, including the modulation of NO and cGMP signaling pathways (Taghi Mansouri et al., 2013
In a study of 306 hypodiploid patients from 16 ALL cooperative groups treated between 1997 and 2013, a subgroup of 228 patients (42 who underwent HSCT) with 44 or fewer chromosomes who achieved remission were analyzed.[97][Level of evidence C2] Favorable prognostic factors included a chromosome number of 44 (compared with 43 or fewer), MRD less than 0.01% after induction, and treatment on an MRD-stratified protocol that intensified therapy for patients with higher MRD after induction
(Japan) 1998;72:153157
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