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This comprehensive metabolic shift results in enhanced lipid utilization (lower cellular fat accumulation) and an efficient use of nutrients, echoing the metabolic effects of calorie restriction or exercise at the cellular scale

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24 patients with ME/CFS, 25 patients with long COVID and 24 healthy controls (HC) underwent brain (pregenual and dorsal anterior cingulate cortex, respectively, pgACC and dACC) and calf muscle MRS scanning at 7 Tesla, followed by a computerised cognitive assessment