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Mechanisms underlying morphine analgesic tolerance and dependence
Guidelines from the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) prioritize the use of GLP-1 RAs for patients with DKD who have cardiovascular comorbidities
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Some research protocols have explored doses up to 4.5 mg weekly, which showed slightly greater efficacy in the phase 2 dose-finding trial but also increased side effect burden
