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Food supplement cocoa flavanol is shown to boost the NAD + and NADH content, stimulate sirtuin metabolism, reduce cellular H 2 O 2 production as well as OxS, and improve mitochondrial function in PASC patients 527

The presence of fatigue in patients with cancer with palliative needs is of risk of being overseen by health care personnel due to difficulties in identifying the symptom but also due to a lack of enhanced knowledge of mechanisms causing fatigue

531,532 When opioids are prescribed, very close monitoring of the patient is advised