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doi:10.1002/jum.14340
In REDEFINE 1, adults with obesity or overweight (without diabetes) treated with CagriSema had a mean body weight reduction of 20.4% at 68 weeks under the treatment-policy estimand, compared with 3.0% on placebo

These improvements were quantified through objective measurement techniques including optical coherence tomography, which provides cross-sectional images of skin structure, and three-dimensional surface analysis systems that precisely measure wrinkle depth and skin texture parameters

The exact duration depends on the specific formulation and storage conditions, so always check the label
