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45,46 A significant amount of C18-PUFAs are released from the membranes by phospholipases 4749 and are oxidized by the same enzymatic systems responsible for the formation of eicosanoids and docosanoids to produce the octadecanoids

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The phosphorylation of AMPK1 is critical for increasing autophagy and maintaining mitochondrial homeostasis in response to fatty acids

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