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The results indicate a protective role of GSTP1 by enhancing GSH-conjugation, which might lead to a reduced protein modification, and suggest a second protective role by interfering with the unfolded protein response, thereby preventing apoptosis

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If Vitamin B12 deficiency develops, neurological symptoms may appear, and if untreated for long periods, damage can become permanent

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Nintedanib and pirfenidone can slow the progression of the disease

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FIGURE 5 Inhibition of the NF-B Pathway by GPX4 Activator We further demonstrated that GPX4 activator can modulate GPX4 mediated events

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