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Intracellular glutathione in human hepatocytes incubated with S-adenosyl-Lmethionine and GSH-depleting drugs

For example, phycocyanin (Li et al., 2017b) and -carboline alkaloids found in Xuelingzhi ( Polygonum aviculare , has also been shown to inhibit the NF-B pathway (Li et al., 2017b), thus reducing the secretion of ECM components and pro-inflammatory cytokines/chemokines, such as IL-6, CCL2, and CXCL1 (Li et al., 2017a)

The crossover design strengthens the reliability of within-subject comparisons and offers robust insights into pharmacokinetic performance