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which necessitates focusing on inhibition of RSKs which are the downstream effectors of the ERK/MAPK signaling cascade
As the leading cause of chronic joint pain and functional disability, OA affects over 595 million individuals worldwide, with incidence rates escalating with aging populations and obesity epidemics [3, 4]
Most of the GSH in antioxidant defense in cells is utilized by three members of glutathione peroxidase (GPx) family (Brigelius-Flohe, 1999) and by one of the peroxiredoxins (Prdx 6)
