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In some embodiments, the otic composition or formulation comprises less than 10% by weight of water

The ability of four recombinant human GSTs (hGST A1-1, hGST M1-1, hGSTP1-1 and hGST T1-1) to catalyze the GSH conjugation of reactive metabolites of clozapine, formed in vitro by human and rat liver microsomes and drug-metabolizing P450 BM3 mutantP450 102A1M11H, has been studied [33]

[DOI] [PubMed] [Google Scholar] 37.Stamler J., Brown I.J., Daviglus M.L., Chan Q., Kesteloot H., Ueshima H., Zhao L., Elliot P

This technique uses computational biology to screen up to millions of potential compounds for predicted effect on target binding, drug metabolism, and central nervous system penetrance