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Methods 40 GD patients with untreated mild active GO and stable thyroid function were randomly assigned to the Mediterranean diet (MD) naturally enriched with selenium (MD group) or a free diet (FD group)

A modified MISI computed on cubic splines of the measured data, resulting in improved identification of glucose peak and nadir, was compared with the original method yielding an increased correlation (=0.576) with the clamp measurement of peripheral insulin sensitivity as compared to the original method (=0.513)

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