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A sequence variation (I148M) in PNPLA3 associated with nonalcoholic fatty liver disease disrupts triglyceride hydrolysis

The antimalarial medication quinine has long been used for cramp relief, but after increasing reports of side effects, most severely disseminated intravascular coagulopathy [193], the FDA limited and provided guidelines for the amount of quinine readily available in common formulations [194]

Although the evidence is compelling that cysteine S -conjugate -lyase reactions contribute to the nephrotoxicity of DCVC and other cysteine S -conjugates derived from halogenated alkenes, as noted earlier, the sulfoxides of the cysteine S -conjugate and mercapturates may be even more toxic than the cysteine S -conjugate (Lash et al., 1994, Lash et al., 2003, Werner et al., 1996)