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Moreover, agrin-treated pericytes exhibited elevated levels of ROS and Fe 2+ , along with reduced expression of GPX4 and FTH1, thereby promoting ferroptosis, suppressing pericyte proliferation, and compromising blood-brain barrier function

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161 Although many traditional formulations are supported by in vitro and in vivo studies, 162 the precise pharmacological effects of individual herbs on inner ear physiology are often incompletely characterized