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The precise contribution of GIP receptor activation to weight reduction remains an area of active study

Ito FK, Kato I, Yanatori T, Murohara S, Toyokuni

Regulatory agencies apply stricter benefit-risk thresholds for obesity treatments than for life-threatening conditions, and tesofensines stimulant-like cardiovascular effects did not meet that threshold despite producing 10% mean weight loss

Similar to the findings of other studies in the STEP trial program 7,27 , exploratory outcomes showed that in the semaglutide group 80% of participants with prediabetes at baseline reverted to normoglycemia by the end of the trial (compared with 37% of those receiving placebo), while 99% of participants with normoglycemia at baseline maintained normoglycemia at the end of the trial (compared with 86% with placebo)