what is one reaction that involves glutathione Glutathione-Mediated Conjugation of Anticancer Drugs: An Overview of Mechanisms and Biological Significance for Drug Detoxification and Bioactivation Frontiers | Research progress of
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10.1038/s41388-018-0480-0 Oncogene 93 NavarroG.AllardC.MorfordJ
J.JayasingheK.GlassfordN.BaileyM.JohnsonD
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Once the glucuronide conjugation and sulfation pathways are saturated, excess acetaminophen is oxidized via the cytochrome P450 microsomal enzyme, resulting in the formation of NAPQI, a highly toxic metabolite [111]
