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doi: 10.1016/j.cell.2015.07.017

That kind of structure is often more successful than layering every active across the full face every night

E.StreltsovV.McCollG.et al (2017)

Continuous use advantages include maintaining peak benefits without decline periods, avoiding the uncertainty of whether improvements will persist after breaks, simplifying routine through consistency, and potentially maximizing cumulative collagen synthesis through sustained stimulation over months to years
