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12,13,14,15 The principal Cu chaperones include COX17 (which delivers Cu to cytochrome c oxygenase), CCS (Cu chaperone for superoxide dismutase, which delivers Cu to superoxide dismutase 1), and ATOX1 (which delivers Cu to ATP7A and ATP7B)

Whether this would be a proportional safety measure depends on the absolute prevalence of this interaction, which is currently not known

Apply a small amount to a discrete area, wait 24 to 48 hours, and check for reaction before proceeding with scalp application

2020;36(5):e3309