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Additionally, activating the SIRT1/Nrf2/p62 pathway can promote the healing of diabetic foot ulcers, possibly mediated by autophagy-dependent ferroptosis ( Together, the diverse roles of SIRT1 across multiple disease types underscore its significance as a promising therapeutic target

doi: 10.1093/jnci/djh320

Disease Management and Clinical Outcomes

ROS and RNS production are facilitated by pattern recognition receptors [C-reactive protein (CRP), toll-like receptors] capable of recognizing pathogen (bacterial/viral)-associated molecular patterns and/or damage-associated molecular patterns in apoptotic or damaged cells (92100) (Figure 6)