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10.1152/ajpregu.00167.2016 20 DerrienT.JohnsonR.BussottiG.TanzerA.DjebaliS.TilgnerH.et al

doi: 10.1021/acs.jafc.0c02476 108

Cancer patients genomic-wide aberrant and variable histone modifications lead to heterogeneity of chromatin accessibility in different tumor subpopulations, which in turn causes heterogeneity in the expression of genes involved in cell proliferation, differentiation, and survival causing TME heterogeneity [68,77]

A decrease in the expression of genes associated with several cellular functions was also detected (e.g., neuron development, gliogenesis, chemotaxis, extracellular matrix organization, axon guidance, oligodendrocyte differentiation)