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However, to date, oligonucleotide therapeutics are still facing some technological obstacles, such as how to achieve efficient oligonucleotide delivery to target organs or tissues, how to overcome off-target interactions [4952], and how to address the sequence- and chemistry-dependent toxicity and saturation of endogenous RNA processing pathways [53, 54]

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Similarly, Quzhou Fructus Aurantii Extract (QFAE) attenuated NF-B signaling in LPS-stimulated macrophages and a mouse acute lung injury model, significantly lowering Tumor Necrosis Factor-Alpha (TNF-), IL-6, and IL-1 levels, while enhancing IL-10 expression and reducing tissue pathology (Li et al., 2020)