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Although undermethylation is more common with the MTHFR gene, overmethylation may instead be the case for some

The antimalarial medication quinine has long been used for cramp relief, but after increasing reports of side effects, most severely disseminated intravascular coagulopathy [193], the FDA limited and provided guidelines for the amount of quinine readily available in common formulations [194]

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diluted 1:5000) for 1 h at room temperature in 5% milk in 1 TBS + 0.1% Tween 20, bands were visualized using ECL solution (GE Healthcare, RPN2106, Thermo Fisher Scientific, cat#80196) and calibrated using a ChemiDoc Imaging System (Bio-Rad, Hercules, CA, USA)