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To identify these clusters, we used thirty-three variables in total, which included standard sleep macrostructure variables, time spend in each sleep stage, global absolute delta power, left and right hemispheric delta power, and the IAI (Supplementary Table 7)

The authors suggest that the increase in levodopa metabolites might be linked to increased levodopa decarboxylase activity, possibly due to changes in the microbiota (e.g., Enterococcus faecalis has the ability to convert levodopa into dopamine) [193]

For biochemical assays, total liver lipids were extracted using chloroform/methanol (21, v/v)